But this factor has an easy solution, there are now natural pills and lubricants that help Zyplex woman in that aspect and thus achieve orgasm. - Drug use : Zyplex most negative substance for people in Zyplex sexual field is alcohol . It causes erectile dysfunction, and can produce anorgasmia. It influences Zyplex central nervous system (CNS) and Zyplex autonomic nervous system (ANS), which controls sexual arousal.